A Time for Metabolism and Hormones

The circadian clock controls a large variety of neuronal, endocrine,
behavioral and physiological responses in mammals. This control is exerted in
large part at the transcriptional level on genes expressed in a cyclic manner. A
highly specialized transcriptional machinery based on clock regulatory factors
organized in feedback autoregulatory loops governs a significant portion of the
genome. These oscillations in gene expression are paralleled by critical events of
chromatin remodeling that appear to provide plasticity to circadian regulation.
Specifically, the NAD+
-dependent deacetylases SIRT1 and SIRT6 have been linked
to circadian control of gene expression
[Cham: 2016]

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