Characterization of labrenzin biosynthesis in marine alphaproteobacterium Labrenzia sp. PHM005

Nature has always been a great provider of resources for humankind to produce food and
materials, build communities and make their overall life easier. Historically, natural plant products
were the first to be medically used in treatments of different kinds of diseases, since the ancient
civilizations of Mesopotamia, Egypt, China or India (Cragg and Newman, 2013). One of the biggest
historical outbreaks in fighting against bacterial infections and malaria were some well-known
natural products such as penicillin isolated from Penicillium, quinine isolated from the bark of
Cinchona species or artemisinin isolated from wormwood Artemisia afra. Other plants used for the
isolation of anticancer compounds were alkaloids paclitaxel (Taxol) from Taxus brevifolia and
vinblastine from Catharanthus roseus. Whereas in the traditional medicine the total plant extract
would be applied for a certain remedy, the modern medicine aims to the application of standardized
protocols, safety, controlled dosage and precise molecular targeting in disease treatments. That
inevitably requires isolation of the active compound and subsequent pharmacokinetic,
pharmacodynamic and other analyses for a proper drug development.
[Madrid: 2021]

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