High Density Lipoproteins

In both epidemiological and clinical studies as well as the meta-analyses thereof,
low plasma levels of high-density lipoprotein (HDL) cholesterol (HDL-C)
identified individuals at increased risk of major coronary events. Observational
studies also found inverse associations between HDL-C and risks of ischemic
stroke, diabetes mellitus type 2, and various cancers. In addition, HDLs exert
many effects in vitro and in vivo which protect the organism from chemical or
biological harm and thereby may interfere with the pathogenesis of atherosclerosis,
diabetes, and cancer but also other inflammatory diseases. Moreover, in several
animal models transgenic overexpression or exogenous application of apolipoprotein Α-I (apoA-I), the most abundant protein of HDL, decreased or prevented the
development of atherosclerosis, glucose intolerance, or tissue damage induced by
ischemia or mechanical injury.
[Cham: 2015]

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