Artículos
Nucleic acid detection using a universal electrochemical sensor for SNS differentiation
Editorial: CEPRECYT
Licencia: Creative Commons (by-nc-sa)
Autor(es): Calvo-Marzal, Percy; [et al.]
Licencia: Creative Commons (by-nc-sa)
Autor(es): Calvo-Marzal, Percy; [et al.]
Nucleic acid detection with high sensitivity and selectivity capabilities could aid in the diagnosis of varies diseases such as: infections, cancer, among others. Discrimination of a mismatch or single nucleotide substitution (SNS) is challenge due to a minimum pair to pair formation double strand needed to stabilize the structure. Here we present a new approach to atinge the needed stability by using additional segments strains to favored stabilization. The use of additional complementary strains facilitates the discrimination of a SNS in a cooperative way.
[2018]
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