Self-Assembled Molecules - New Kind of Protein Ligands

This collection of publications serves as the introduction to a new approach in biology and pharmacology: exploiting the peculiar properties of supramolecular systems, particularly ribbonlike micellar structures which constitute an entirely new
category of protein ligands. The novelty of the problem is reflected by the specific
character of such ligands but also by the way in which they bind to proteins - a
mechanism unlike "classic" ligand binding. Among described problems of importance are enhancement of immune complexation by supramolecular ligands and
their possible use as carriers for drugs. Many of those supramolecular compounds,
including Congo red and Evans blue, have long been used as dyes and amyloid
markers; however, we are only now beginning to understand their specific chemistry
and interaction with proteins.
[Cham: 2018]

Compartir: